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What principle did the Declaration of Helsinki establish for conducting research with humans?

  1. Standard legal protocols

  2. Ethical guidelines based on the Nuremberg Code

  3. Financial management of research funds

  4. Safety measures in clinical trials

The correct answer is: Ethical guidelines based on the Nuremberg Code

The Declaration of Helsinki established ethical guidelines for conducting research with humans, known as the Nuremberg Code. This code outlines several principles for ensuring the well-being of research participants and protecting their rights, such as voluntary participation, informed consent, and risk-benefit analysis. Option A is incorrect because legal protocols may not always align with ethical considerations. Option C is incorrect because financial management is not the main focus of the Declaration of Helsinki. Option D is incorrect because while safety measures are important in clinical trials, they are not the primary principle established by the Declaration of Helsinki.